Alert

Updates

COVID-19: Vaccine information and additional resources | Medicaid: The program is changing and you must take steps to keep your UNC Health providers

chlorambucil

Pronunciation: klor AM bue sil

Brand: Leukeran

Leukeran

slide 1 of 1, Leukeran,

2 mg, round, brown, imprinted with GX EG3, L

Image of Leukeran
slide 1 of 1
    

What is the most important information I should know about chlorambucil?

Chlorambucil can increase your risk of bleeding or infection. Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, weakness).

What is chlorambucil?

Chlorambucil is used to treat several types of cancer, including Hodgkin's disease and certain types of leukemia or lymphoma.

Chlorambucil may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking chlorambucil?

You should not be treated with chlorambucil if you are allergic to it, or if you have received chlorambucil in the past without successful treatment of your condition.

You may not be able to receive chlorambucil if you've ever had an allergic reaction to another cancer drug such as bendamustine, busulfan, carmustine, dacarbazine, ifosfamide, lomustine, mechlorethamine, melphalan, streptozocin, or temozolomide.

Tell your doctor if you have ever had:

  • kidney disease;
  • liver disease;
  • a seizure;
  • a head injury or brain tumor; or
  • if you have received radiation or chemotherapy within the past 4 weeks.

Taking chlorambucil may increase your risk of developing other types of cancer. Talk to your doctor about your specific risk.

Do not use chlorambucil if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine.

This medicine may affect fertility (ability to have children) in both men and women. However, women should still use birth control to prevent pregnancy because chlorambucil can harm an unborn baby.

You should not breastfeed while using this medicine.

How should I take chlorambucil?

You must remain under the care of a doctor while you are using chlorambucil.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Chlorambucil is usually taken for 3 to 6 weeks. Follow your doctor's dosing instructions very carefully.

Chlorambucil can increase your risk of bleeding or infection. You will need frequent medical tests. Your cancer treatments may be delayed based on the results.

Store chlorambucil tablets in the refrigerator.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include agitation, fast heartbeats, skin rash, bruising, bleeding gums, nosebleeds, trouble breathing, or signs of infection (fever, chills, weakness).

What should I avoid while taking chlorambucil?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Do not receive a "live" vaccine while using chlorambucil. The vaccine may not work as well and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

What are the possible side effects of chlorambucil?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  • a seizure;
  • an unusual mass or lump;
  • severe vomiting or diarrhea;
  • new or worsening cough;
  • bone marrow suppression --dizziness, pale lips or fingernail beds, fast heart rate, getting easily tired or short of breath;
  • liver problems --loss of appetite, stomach pain (upper right side), dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • low blood cell counts --fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Common side effects may include:

  • bone marrow suppression;
  • low blood cell counts;
  • missed menstrual periods;
  • nausea, vomiting, diarrhea; or
  • sores or white patches in or around your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect chlorambucil?

Other drugs may affect chlorambucil, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your doctor or pharmacist can provide more information about chlorambucil.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2021 Cerner Multum, Inc. Version: 6.01. Revision date: 12/3/2020.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by End-User License Agreement, which can be accessed by clicking on this link.