What is the Precision Health Genetic Screen program?
The Precision Health Genetic Screen program is a pilot clinical implementation of genomic screening in 1000 otherwise healthy adults in primary care practices in the UNC Health System.
What conditions are addressed by the Precision Health Genetic Screen?
The Precision Health Genetic Screen includes genetic testing for 11 genes linked to Hereditary Breast and Ovarian Cancer syndrome, Lynch syndrome, and Familial Hypercholesterolemia. Collectively, these 3 conditions are known as CDC Tier 1 conditions.
What specific genes are examined?
Why are these particular genes addressed by the Precision Health Genetic Screen?
The goal is to identify the 1-3% of the population that has a high risk of treatable disease and improve patient outcomes. Of note, the Precision Health Genetic Screen is sponsored by the UNC Program for Precision Medicine and is offered at no cost to patients.
Why should patients consider this particular test?
The Precision Health Genetic Screen is sponsored by the UNC Program for Precision Medicine and is offered at no cost to patients.
What patients are eligible?
This new genetic screening test is available to patients age 18 and older. If the patient has a strong family history of one of the genetic conditions, then this screening test might not be right for them.
About the Test Results
What do positive/abnormal test results mean?
A positive test result means that the patient has a variant that increases their risk of developing cancer or heart disease. The positive result does not mean that they will definitely develop cancer or heart disease, but it does mean that they have a much higher chance to develop it than the average person. Early treatment or screening might be advised for this patient. You might refer the patient to a genetic counselor. Only about 2% of the people in the United States have one of these genetic conditions, so most patients will receive negative/normal results.
What do negative/normal test results mean?
A negative test result means that the patient does not carry any known variants in the genes evaluated by the Precision Health Genetic Screening test. It does not mean that the patient will never develop cancer or high cholesterol, but they most likely do not have one of these genetic risk conditions.
Interested in offering the PHGS to your patients?